Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly.
Exp Gerontol
; 38(10): 1065-70, 2003 Oct.
Article
en En
| MEDLINE
| ID: mdl-14580859
The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Mitocondriales
/
Sirtuinas
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Histona Desacetilasas
/
Longevidad
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Exp Gerontol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Reino Unido