Total synthesis and conformational analysis of the antifungal agent (-)-PF1163B.
Org Lett
; 5(22): 4049-52, 2003 Oct 30.
Article
en En
| MEDLINE
| ID: mdl-14572246
[reaction: see text]. (-)-PF1163B, a new macrocyclic antifungal antibiotic isolated from Streptomyces sp., has been prepared in eight steps from (S)-citronellene. The key step is a ring-closing metathesis reaction of an ester and amide derivative obtained from a substituted N-methyl-l-tyrosine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conformación Molecular
/
Antifúngicos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos