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Properties of HIV membrane reconstituted from its recombinant gp160 envelope glycoprotein.
Cornet, B; Decroly, E; Thines-Sempoux, D; Ruysschaert, J M; Vandenbranden, M.
Afiliación
  • Cornet B; Laboratoire de Chimie-Physique des Macromolécules aux Interfaces, Université Libre de Bruxelles, Belgium.
AIDS Res Hum Retroviruses ; 8(10): 1823-31, 1992 Oct.
Article en En | MEDLINE | ID: mdl-1457195
Human immunodeficiency virus (HIV) membrane has been reconstituted from the recombinant envelope glycoprotein precursor (gp160) by a detergent dialysis technique. Electron microscopy shows that gp160-virosomes are spherical vesicles with a mean diameter identical to that of viral particles. Enzyme-linked immunosorbent assay and immunogold labeling demonstrate efficient association of gp160 with lipid vesicles and proteolysis treatment reveals an asymmetric insertion with about 90% of glycoproteins having their gp120-moiety pointing outside. Glycoproteins are organized as dimers and tetramers and gp160 retains its ability to specifically bind CD4 receptor after reconstitution into virosome.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Precursores de Proteínas / Productos del Gen env / VIH-1 Límite: Humans Idioma: En Revista: AIDS Res Hum Retroviruses Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 1992 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Precursores de Proteínas / Productos del Gen env / VIH-1 Límite: Humans Idioma: En Revista: AIDS Res Hum Retroviruses Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 1992 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos