The yeast G protein alpha subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160.
Mol Cell
; 12(2): 517-24, 2003 Aug.
Article
en En
| MEDLINE
| ID: mdl-14536090
In yeast Saccharomyces cerevisiae the G protein betagamma subunits (Ste4/Ste18) have long been known to transmit the signal required for mating. Here we demonstrate that GTPase-deficient mutants of Galpha (Gpa1) directly activate the mating response pathway. We also show that signaling by activated Gpa1 requires direct coupling to an RNA binding protein Scp160. These findings suggest an additional role for Gpa1 and reveal Scp160 as a component of the mating response pathway in yeast.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
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ARN
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Proteínas Nucleares
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Proteínas de Saccharomyces cerevisiae
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Subunidades alfa de la Proteína de Unión al GTP
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Proteínas de la Membrana
Idioma:
En
Revista:
Mol Cell
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos