Developmentally-regulated coexpression of vimentin and cytokeratins in the rat inner ear.
Hear Res
; 62(1): 1-10, 1992 Sep.
Article
en En
| MEDLINE
| ID: mdl-1385376
In the present study the expression of vimentin-type intermediate filament proteins and cytokeratins was studied immunohistochemically in the rat inner ear from 12 days postconception up to 40 days after birth. With the use of a broad spectrum monoclonal antibody, cytokeratin expression was found to be present in the whole epithelial lining except for the sensory cells, throughout all the developmental stages examined. Vimentin was detected in the mesenchymal cells, the mesenchyme-derived tissues and the intermediate cells of the stria vascularis, confirming their origin from melanocyte precursor cells. In addition, the coexpression of vimentin and cytokeratins in the epithelial lining of the membranous inner ear was found to be developmentally regulated. During the final stages of differentiation, vimentin expression disappeared from the majority of the cell types. In the mature cochlea the coexpression of vimentin and cytokeratins was still found in the supporting cells of the organ of Corti, in the cells of Claudius and in external sulcus cells. As far as we could conclude from this study, the sensory cells showed only vimentin expression but not cytokeratin expression. A possible relationship between vimentin expression in adult epithelial cells of the inner ear and a specialised function of these cells is discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vimentina
/
Cóclea
/
Queratinas
/
Oído Interno
Límite:
Animals
Idioma:
En
Revista:
Hear Res
Año:
1992
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Países Bajos