[Changes in the ATP-ase activity of skeletal muscle nuclei of rabbits with dystrophy and following their delipidation]. / Zminy ATF-aznoï aktyvnosti iader skeletnykh m'iaziv kroliv za dystrofiï ta pislia ïkh delipiduvannia
Ukr Biokhim Zh
; 48(6): 727-33, 1976.
Article
en Uk
| MEDLINE
| ID: mdl-138232
The level of the ATPase activity in the skeletal muscles nuclei with experimental muscular dystrophy and the sensitivity to bivalent (Mg2+, Ca2+) and univalent (Na+, K+) cations under conditions of delipidation were studied. It is established that among ATPases of the young rabbit skeletal muscles nuclei there is ATPase sensitive to monovalent cations: the presence of Na+ or K+ produces a 45% increase in its activity in some experiments as compared to the initial level. This activation is attributed to Mg2+, Ca2+-ATPase the action of which is not realized in the presence of EGTA-chelator of calcium ions. A decrease in the total ATPase activity in the skeletal muscles nuclei resulted from the experimental muscular dystrophy development occurs due to a decrease in the Mg2+, Ca2+-ATPase activity as the ability for activation by the monovalent cations is practically lost under these conditions. Delipidation of the skeletal muscles nuclei, which results in their loss of some phospholipids and cholesterin, is accompanied by the ATPase activity decrease. At the same time the nuclei ATPase activity lose its ability to activate by monovalent cations: Na+, K+. A conclusion is made that during delipidation the decrease in the total ATPase activity is due to a decrease in the activity of its Mg2+, Ca2+-part.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Núcleo Celular
/
Adenosina Trifosfatasas
/
Lípidos
/
Músculos
/
Distrofias Musculares
Límite:
Animals
Idioma:
Uk
Revista:
Ukr Biokhim Zh
Año:
1976
Tipo del documento:
Article
Pais de publicación:
Ucrania