Analysis of the antigenic epitopes of hepatitis B surface antigen involved in the induction of a protective antibody response.

Waters, J A; Brown, S E; Steward, M W; Howard, C R; Thomas, H C

Waters, J A; Brown, S E; Steward, M W; Howard, C R; Thomas, H C.

Afiliación

Waters JA; Department of Medicine, St. Mary's Hospital Medical School, Imperial College, London, U.K.

Virus Res ; 22(1): 1-12, 1992 Jan.

Article en En | MEDLINE | ID: mdl-1371369

RESUMEN

Vaccination with hepatitis B surface antigen (HBsAg) has shown that antibody directed against the common 'a' determinant of this antigen is protective against infection with hepatitis B virus (HBV). In this study the antigenic epitopes of the 'a' determinant have been analysed by competitive inhibition assays and by binding studies to synthetic peptides using a panel of monoclonal antibodies prepared against HBsAg, all of which are shown to recognise the common group determinant. One murine monoclonal antibody used in this study, RFHBs1, has been shown previously to block infectivity of HBV in susceptible chimpanzees ((1983) J. Med. Virol. 16, 89-95). This antibody bound to a cyclical synthetic peptide analogue of amino acids 124 to 137 of the major HBsAg polypeptide.

Asunto(s)

Epítopos/inmunología; Anticuerpos contra la Hepatitis B/inmunología; Antígenos de Superficie de la Hepatitis B/inmunología; Virus de la Hepatitis B/inmunología; Hepatitis B/inmunología; Anticuerpos Monoclonales/inmunología; Unión Competitiva; Western Blotting; Humanos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus de la Hepatitis B / Hepatitis B / Anticuerpos contra la Hepatitis B / Antígenos de Superficie de la Hepatitis B / Epítopos Límite: Humans Idioma: En Revista: Virus Res Asunto de la revista: VIROLOGIA Año: 1992 Tipo del documento: Article Pais de publicación: Países Bajos

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