The calibrated automated thrombogram (CAT): a universal routine test for hyper- and hypocoagulability.
Pathophysiol Haemost Thromb
; 32(5-6): 249-53, 2002.
Article
en En
| MEDLINE
| ID: mdl-13679651
By using a "slow" fluorogenic thrombin substrate and continuous comparison to a simultaneously run calibrator, thrombin generation can be monitored automatically, on line, in clotting PPP or PRP at a throughput of up to 100 samples per hour. The resulting "Thrombogram" in PPP measures hypocoagulability (haemophilias, oral anticoagulants, heparins (-likes), direct inhibitors) and hypercoagulabilities (AT deficiency, prothrombin hyperexpression, prot. C and S deficiency, factor V Leiden, oral contraceptives). In PRP it is diminished in thrombopathies, in von Willebrand disease, by antibodies blocking GPIIb-IIIa or GPIb, or by antiplatelet drugs like aspirin and clopidogrel. Lupus anticoagulant both retards and increases thrombin generation. The thrombogram thus appears to be a broad function test of the haemostatic-thrombotic mechanism of the blood.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos de la Coagulación Sanguínea
/
Pruebas de Coagulación Sanguínea
/
Trombina
Límite:
Humans
Idioma:
En
Revista:
Pathophysiol Haemost Thromb
Asunto de la revista:
ANGIOLOGIA
/
HEMATOLOGIA
Año:
2002
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Suiza