Protective efficacy of a serogroup B meningococcal vaccine in Sao Paulo, Brazil.
Lancet
; 340(8827): 1074-8, 1992 Oct 31.
Article
en En
| MEDLINE
| ID: mdl-1357461
ABSTRACT
PIP: In 1990, researchers compared data on 112 3 month-6 year old children who received a Cuban produced, outer-membrane-protein-based serogroup B meningococcal vaccine (cases) and lived in greater Sao Paulo, Brazil with data on 409 age and neighborhood matched controls to determine the protective efficacy of the vaccine against serogroup B meningococcal disease (Neisseria meningitidis). Health workers began administering the vaccine in 1989 to control an epidemic of serogroup B meningococcal disease in the area. In fact, in mid-1989 and early 1990, the rates of serogroup B meningococcal disease in 1-6 year old children in Sao Paulo were 2.07/100,000 and 2.3/100,000, respectively. Even though only 44% of serogroup B meningococcal isolates corresponded with the vaccine type strain (B:4:P1:15), many isolates had man of the same serotype or subtype antigens as the vaccine type strain. Thus the vaccine was able to protect against some other serogroup B meningococcal strains other than the vaccine type strain. Vaccine efficacy for 4-year old children was 74%, but was much lower for 24-47 month old children (47%) and 24-month old children (-37%). The change in the log odds ratio for vaccination by age was linear and significant (p=.057). The researchers suggested that poor vaccine efficacy among younger children may reflect a need for more boosting to achieve protective levels of immunity. The results showed that the Cuban-produced vaccine could contribute to control of outbreaks of serogroup B meningococcal disease by protecting older children and adults from the disease. Researchers need to conduct additional studies of the vaccine and other possible serogroup B meningococcal vaccines.
Palabras clave
Adult; Age Factors; Americas; Biology; Brazil; Caribbean; Case Control Studies; Central Nervous System; Central Nervous System Effects; Child; Control Groups; Cuba; Demographic Factors; Developing Countries; Diseases; Infections; Latin America; Matched Groups; Methodological Studies; North America; Physiology; Population; Population Characteristics; Prospective Studies; Research Methodology; Retrospective Studies; South America; Studies; Urban Population; Vaccines; Youth
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas Bacterianas
/
Brotes de Enfermedades
/
Vacunación
/
Infecciones Meningocócicas
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Lancet
Año:
1992
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Reino Unido