[The spontaneous neuronal activity of the hippocampus during the modulation of the theta rhythm by cholinergic substances]. / Spontannaia aktivnost' neironov gippokampa pri moduliatsii teta-ritma kholinergicheskimi veshchestvami.
Zh Vyssh Nerv Deiat Im I P Pavlova
; 42(5): 944-54, 1992.
Article
en Ru
| MEDLINE
| ID: mdl-1336281
Background activity of the hippocampal neurons, extracellularly recorded in waking chronic rabbits, was analysed in control state and after systemic injection of physostigmine and scopolamine. Similar analysis was done in the hippocampus chronically deprived of ascending brain stem afferents. Cholinergic drugs controlled the number of hippocampal neurons with theta-modulation and the degree of its stability but not the frequency. Activation of cholinergic theta-rhythm resulted also in regularization of activity with suppression of delta-modulation and complex spike discharges; its blockade was accompanied by the opposite changes. Both drugs shifted the level of background activity in the majority of neurons, but the overall mean frequency did not vary between the states. Regression analysis demonstrated significant negative correlations with dominating decrease in the level of activity in high-frequency neurons ( > 25 sp/s) and its increase in low-frequency ones ( < 25 sp/s) after injection of both drugs. Stability of the overall mean frequency and uniformity of its shifts presumably indicate that the frequency, unlike the pattern of the background activity, is not directly controlled by the cholinergic septal input.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Parasimpatolíticos
/
Ritmo Teta
/
Hipocampo
/
Neuronas
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
Ru
Revista:
Zh Vyssh Nerv Deiat Im I P Pavlova
Asunto de la revista:
NEUROLOGIA
Año:
1992
Tipo del documento:
Article
Pais de publicación:
Rusia