Syntheses of leukotriene-derivatives.

Bestmann, H J; Röder, T

Bestmann, H J; Röder, T.

Afiliación

Bestmann HJ; Institute of Organic Chemistry, University of Erlangen-Nürnberg, FRG.

Eicosanoids ; 5 Suppl: S1-3, 1992.

Article en En | MEDLINE | ID: mdl-1333249

RESUMEN

Some general synthetic routes for the synthesis of cysteinyl-leukotriene derivatives derived from stable building blocks are described. D6-LTE4, a metabolically stable isotopically labelled mass spectrometric internal standard, 20-hydroxy-LTE4, the unnatural 6-epi-LTE4; LTE3, a LT-derivative with 2-amino-thiophenol as a modified "amino-acid" and 14,15-dehydro-LTA4 were prepared. The compounds were tested in a LT-inhibition assay using a monoclonal antibody.

Asunto(s)

Leucotrienos/síntesis química; Deuterio; Leucotrieno A4; Leucotrieno E4; Leucotrienos/química; Conformación Molecular; Estructura Molecular; SRS-A/análogos & derivados; SRS-A/síntesis química; SRS-A/química

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucotrienos Idioma: En Revista: Eicosanoids Asunto de la revista: BIOQUIMICA Año: 1992 Tipo del documento: Article Pais de publicación: Alemania

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