Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins.
Biochem Biophys Res Commun
; 184(3): 1425-31, 1992 May 15.
Article
en En
| MEDLINE
| ID: mdl-1317174
We examined the potential role of a guanine nucleotide-binding protein in the biosynthesis of paf-acether (paf) and the release of beta-hexosaminidase during antigenic stimulation of cultured mouse bone marrow-derived mast cells. Unlike pertussis toxin, cholera toxin treatment enhanced the antigen-stimulated production of paf and calcium mobilisation without affecting acetyltransferase activation and cell degranulation. The level of intracellular cAMP doubled in cholera toxin-treated cells. Our data suggest that a cholera toxin-sensitive guanine nucleotide-binding protein is involved in the IgE receptor-mediated signal transduction leading to paf production most probably at the level of Ca2+ influx.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor de Activación Plaquetaria
/
Calcio
/
Proteínas de Unión al GTP
/
Mastocitos
Límite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1992
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos