[Effectiveness of phosphonoformic acid in herpes infections]. / Ucinnost kyseliny fosfonomravencí na herpetická onemocnení.
Cesk Farm
; 41(1): 1-4, 1992 Feb.
Article
en Cs
| MEDLINE
| ID: mdl-1316808
The antiviral efficacy of phosphonoformic acid (PFA) was examined on tissue cultures of the human embryonal lungs against the viruses herpes simplex type 1 and 2, herpes zoster, and the human cytomegalovirus using the method of the inhibition of the cytopathic effect and against herpes simplex type 1 and 2 on the tissue cultures of Vero cells using the methods of the inhibition of plaque formation. PFA was demonstrated to inhibit the reproduction of the viruses under study in both tests on tissue cultures. In persistence studies, the cytomegalovirus was not isolated back from the cells of the human embryonal lungs, which gave evidence of its greater sensitivity to PFA. In in vivo experiments, PFA in the form of a 3% ointment suppressed herpetic dermatitis on the guinea-pig skin, when treatment started 6, 24 and 48 hours after infection. In a preliminary experiment on rabbit corneas, an ointment with 3% PFA inhibited herpetic keratoconjunctivitis in time intervals of 1 and 3 hours after infection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Ácido Fosfonoacético
/
Infecciones por Herpesviridae
Límite:
Animals
Idioma:
Cs
Revista:
Cesk Farm
Año:
1992
Tipo del documento:
Article
Pais de publicación:
República Checa