Pharmacokinetics of quinine, quinidine and Cinchonine when given as combination.
Southeast Asian J Trop Med Public Health
; 23(4): 773-6, 1992 Dec.
Article
en En
| MEDLINE
| ID: mdl-1298088
Pharmacokinetics of quinine, quinidine and cinchonine when given as a combination were evaluated in Thai patients with falciparum malaria during acute infection and convalescence. The combination of quinine, quinidine and cinchonine was randomly given to thirteen patients at 400 mg or 600 mg (consisting of one-third of each component; 7 patients were enrolled in 400 mg regimen and 6 in 600 mg regimen) intravenously every 8 hours for 7 days. The drug combination was given again at day 35 to define the pharmacokinetics of each drug during convalescence. All patients with the 600 mg regimen had good response with 100% cure rate while patients with the 400 mg regimen had a good initial response but one patient recrudesed on day 46. This particular patient had plasma concentrations of all three drugs lower than the mean values of patients with sensitive responses. The plasma levels of quinine and quinidine obtained from the present study were higher than that expected from one-third of the conventional dose (600 mg) when given alone, suggesting drug combination interaction. The terminal half-lives of each of the three components were prolonged during acute malaria when compared to those obtained during convalescence.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinidina
/
Quinina
/
Alcaloides de Cinchona
/
Malaria Falciparum
/
Antimaláricos
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Southeast Asian J Trop Med Public Health
Año:
1992
Tipo del documento:
Article
País de afiliación:
Tailandia
Pais de publicación:
Tailandia