Screening of malignant pleural effusion by discriminant analysis.
Int J Tuberc Lung Dis
; 7(9): 892-8, 2003 Sep.
Article
en En
| MEDLINE
| ID: mdl-12971675
OBJECTIVE: To assess the value of discriminant analysis as a method of optimizing the discriminant power of routine parameters in differentiating between malignant and non-malignant pleural effusions. METHODS: Retrospective review of the medical records of 245 patients with exudative pleural effusion. RESULTS: The most powerful predictor of the malignant etiology of pleural effusion was a function that consisted of seven variables: age (years); effusion volume (coded as up to one third = 1, up to two thirds = 2, massive = 3); sedimentation rate (mm/h); monocyte count in the peripheral blood (cells/mm3); bloodstained exudate (coded as yes = 1, no = 2); and glucose (mg/dL) and iron (microg/dL) concentration in pleural fluid. This function showed a sensitivity of 77%, specificity of 85%, positive predictive value (PPV) of 76%, negative predictive value (NPV) of 86%, and was able to give an 82% rate of correct classification. In patients aged 50 years or younger, the NPV ranged between 91 and 98%, whereas in those older than 60 years, the PPV was 89%. CONCLUSION: The calculated discriminant function is a simple, rapid, and inexpensive method for screening patients with pleural effusion for malignant etiology.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Derrame Pleural
/
Tamizaje Masivo
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Derrame Pleural Maligno
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Int J Tuberc Lung Dis
Año:
2003
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Francia