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Array painting: a method for the rapid analysis of aberrant chromosomes using DNA microarrays.
Fiegler, H; Gribble, S M; Burford, D C; Carr, P; Prigmore, E; Porter, K M; Clegg, S; Crolla, J A; Dennis, N R; Jacobs, P; Carter, N P.
Afiliación
  • Fiegler H; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
J Med Genet ; 40(9): 664-70, 2003 Sep.
Article en En | MEDLINE | ID: mdl-12960211
OBJECTIVE: The authors describe a method, termed array painting, which allows the rapid, high resolution analysis of the content and breakpoints of aberrant chromosomes. METHODS: Array painting is similar in concept to reverse chromosome painting and involves the hybridisation of probes generated by PCR of small numbers of flow sorted chromosomes on large insert genomic clone DNA microarrays. RESULTS: and CONCLUSIONS: By analysing patients with cytogenetically balanced chromosome rearrangements, the authors show the effectiveness of array painting as a method to map breakpoints prior to cloning and sequencing chromosome rearrangements.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aberraciones Cromosómicas / Análisis de Secuencia por Matrices de Oligonucleótidos Límite: Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Med Genet Año: 2003 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aberraciones Cromosómicas / Análisis de Secuencia por Matrices de Oligonucleótidos Límite: Adult / Child / Child, preschool / Female / Humans / Male Idioma: En Revista: J Med Genet Año: 2003 Tipo del documento: Article Pais de publicación: Reino Unido