Measuring the change in CBV upon cortical activation with high temporal resolution using look-locker EPI and Gd-DTPA.
Magn Reson Med
; 50(3): 483-92, 2003 Sep.
Article
en En
| MEDLINE
| ID: mdl-12939755
A method of simultaneously measuring the changes in cerebral blood volume (CBV) and T(*) (2) that occur on brain activation with high temporal resolution was developed. The method involves measuring the change in the longitudinal relaxation time (T(1)) that occurs following a bolus injection of Gd-DTPA and converting this measurement to a change in blood volume assuming fast exchange. The sequence was optimized for the measurement of changes in CBV with high temporal resolution. A change in CBV of 27 +/- 4% on activation of the primary visual cortex (V1) was measured across four subjects. The time course of changes in T(*) (2) showed a poststimulus undershoot (P = 0.008) corresponding approximately to a period over which CBV was still elevated above baseline, but falling (P = 0.01). The effects of perfusion, nonfulfillment of the assumption of fast exchange and of intrinsic T(1) changes on activation on the model used to calculate the change in CBV are discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Corteza Visual
/
Circulación Cerebrovascular
/
Imagen Eco-Planar
/
Medios de Contraste
/
Gadolinio DTPA
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Magn Reson Med
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2003
Tipo del documento:
Article
Pais de publicación:
Estados Unidos