Occupational asthma due to IgE mediated allergy to the flower Molucella laevis (Bells of Ireland).
Occup Environ Med
; 60(9): 701-3, 2003 Sep.
Article
en En
| MEDLINE
| ID: mdl-12937197
BACKGROUND: About 25% of greenhouse flower and/or ornamental plant growers sensitised to workplace flowers or moulds have occupational asthma, a disease that is suffered by 8% of the growers who cultivate these crops. AIM: To document a case of occupational asthma due to IgE mediated allergy to the flower Molucella laevis. METHODS: and RESULTS: There was a history of work related seasonal asthmatic and rhinoconjunctivitis symptoms in a Molucella laevis grower. Bronchial obstruction following exposure to Molucella laevis was documented by a fall in FEV(1) from 89% to 73% of predicted during seasonal exposure to Molucella laevis. Daily PEF measurements showed a fall from 500 to 250 l/min during this period following withdrawal of inhaled steroids. Bronchial reactivity to inhaled methacholine was increased (PC(20) 1.45 mg/ml). Confirmation of sensitisation to Molucella laevis flower pollen extract was done using an SPT and by demonstration of Molucella laevis specific serum IgE (18 IU/ml; class 4). Specific inhalation challenge with Molucella laevis extract provoked an early and late asthmatic reaction (EAR and LAR) with a fall in FEV(1) compared with control day of 40% and 53% respectively, with associated 5.1-fold increase in absolute sputum eosinophil cell counts and 2.9-fold increase in neutrophil cell counts.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polen
/
Asma
/
Inmunoglobulina E
/
Alérgenos
/
Exposición Profesional
/
Enfermedades Profesionales
Tipo de estudio:
Prognostic_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Occup Environ Med
Asunto de la revista:
MEDICINA OCUPACIONAL
/
SAUDE AMBIENTAL
Año:
2003
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Reino Unido