Man-made mineral fiber hazardous properties assessment using transgenic rodents: example of glass fiber testing.

Bottin, M C; Vigneron, J C; Rousseau, R; Micillino, J C; Eypert-Blaison, C; Kauffer, E; Martin, P; Binet, S; Rihn, B H

Bottin, M C; Vigneron, J C; Rousseau, R; Micillino, J C; Eypert-Blaison, C; Kauffer, E; Martin, P; Binet, S; Rihn, B H.

Afiliación

Bottin MC; Institut National de Recherche et de Sécurité, Vandoeuvre Cedex, France.

Inhal Toxicol ; 15(10): 1017-27, 2003 Sep.

Article en En | MEDLINE | ID: mdl-12928977

RESUMEN

Transgenic BigBlue rats were exposed to CM 44 glass fibers (6.3 mg/m3) by nose only, 6 h/day for 5 days. Two endpoints were examined 1, 3, 14, 28, and 90 days following exposure: fiber biopersistence and mutations in lung DNA. The half-time of the fibers >20 microm was 12.8 days, and mutant frequencies of control and exposed rats were similar across all time points. The mutation spectra of both series were similar after 28 days of fixation time. These results showed that a glass fiber with a high clearance in the lung seems to not present any significant effect on mutagenesis on lung DNA and are in marked contrast to results for asbestos, which caused a twofold mutant frequency increase as described in a previous study.

Asunto(s)

Daño del ADN; Vidrio; Exposición por Inhalación; Animales; Animales Modificados Genéticamente; Lavado Broncoalveolar; Semivida; Masculino; Pruebas de Mutagenicidad; Ratas/genética; Ratas Endogámicas F344; Medición de Riesgo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Exposición por Inhalación / Vidrio Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Inhal Toxicol Asunto de la revista: TOXICOLOGIA Año: 2003 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido

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