Induction of Fos protein in neurons in the medulla oblongata after motion- and X-irradiation-induced emesis in musk shrews (Suncus murinus).
Auton Neurosci
; 107(1): 1-8, 2003 Aug 29.
Article
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| MEDLINE
| ID: mdl-12927221
To clarify the anatomical location of medullary neurons associated with vomiting, the musk shrew (Suncus murinus), a small animal used as a model for emesis, was exposed to various emetic stimuli and patterns of neuronal excitation were investigated by Fos immunohistochemistry. In motion experiments, musk shrews were shaken for 30 min on a tabletop shaker (displacement=25 mm and frequency=1.2 Hz). Ten of fifteen animals vomited frequently (Mo-FV group); the other five animals did not vomit (Mo-NV group). In radiation experiments, X-ray irradiation (10 Gy) of the whole body caused frequent vomiting in all of seven experimental animals (Ra-FV group). In the Mo-FV group, many Fos-immunoreactive (Fos-ir) neurons were detected in the nucleus of the solitary tract (NTS) and the reticular formation. The distribution pattern of Fos-ir neurons in the Mo-NV group was similar to that in the Mo-FV group, but the Mo-NV group had significantly fewer positive neurons in the NTS and the reticular formation around the nucleus ambiguus. In the Ra-FV group, numerous Fos-ir neurons were observed in the area postrema, an area containing no positive neurons in the motion-stimulated animals. The number of Fos-ir neurons in the NTS of the Ra-FV group was not statistically different from that of the Mo-NV group. In the Mo-FV and Ra-FV groups, Fos-ir neurons were clustered in the reticular formation at the dorsal-dorsomedial edge of the nucleus ambiguus at the level of the rostral medulla, while few such clusters were observed in the Mo-NV group. These neurons may play a role in the regulation of the vomiting response.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vómitos
/
Rayos X
/
Bulbo Raquídeo
/
Proteínas Proto-Oncogénicas c-fos
/
Movimiento (Física)
Límite:
Animals
Idioma:
En
Revista:
Auton Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Países Bajos