Effects of hypertonic saline (7.5%) on extracellular fluid volumes in healthy volunteers.
Anaesthesia
; 58(9): 878-81, 2003 Sep.
Article
en En
| MEDLINE
| ID: mdl-12911361
This study evaluated the effects of 7.5% saline on plasma and other extracellular fluid volumes. After baseline measurements, eight healthy postmenopausal female volunteers received 4 ml.kg-1 of hypertonic saline over 30 min. After the fluid infusion, the volunteers were studied for 60 min. Plasma volume was measured using a dilution of 125-iodine-labelled human albumin. Extracellular water and cardiac output were measured by whole body impedence cardiography. The infused volume was 4 ml.kg-1 (average 260 ml). Plasma volume increased rapidly during the infusion (mean +/- standard deviation, 442 +/- 167 ml). At the end of the 1-h follow-up period, plasma volume had increased by on average 465 ml (SD 83). The increase of extracellular water at the end of infusion and at the end of study was 650 ml (SD 93) and 637 ml (SD 192), respectively. The highest serum sodium recorded in the volunteers was 158 mmol.l-1. The effect of 7.5% saline on plasma volume was rapid and lasted for at least 1 h. Plasma volume remained elevated by more than the infused volume at the end of the study. The increase in plasma and extracellular fluid volumes was partly achieved by mobilizing intracellular water to extracellular compartment.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Solución Salina Hipertónica
/
Transferencias de Fluidos Corporales
/
Espacio Extracelular
Límite:
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Anaesthesia
Año:
2003
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
Reino Unido