Changes in size and shape of smooth muscle cells from the portal vein of spontaneously hypertensive rats: an ultrastructural analysis.
Arch Histol Cytol
; 55 Suppl: 95-104, 1992.
Article
en En
| MEDLINE
| ID: mdl-1290681
The portal vein was investigated in male spontaneously hypertensive rats (SHR), from Wistar-Kyoto (WKY) and Wistar strains, in animal 16-20 weeks old. In SHR, the inner circular smooth muscle was unchanged, but the outer longitudinal layer showed marked alterations in shape and size, readily observed in three-dimensional micrographs using scanning electron microscopy. The cells in both Wistar and WKY were elongate and tubular with little variation along their lengths and with a relatively smooth sarcolemma. This applied to both the inner and outer layers of smooth muscle. In contrast, the smooth muscle cells from SHR in the outer layer varied considerably in thickness along their lengths, and had very irregular outlines with numerous pits or depressions of varying sizes. In addition, the cells frequently had major forks or branches. The vasa vasorum running through the muscle layer, fibroblasts and nerve bundles were also identified. Sectioned material (transmission electron microscopy) showed a change in shape and hypertrophy of the smooth muscle cells from the portal vein of SHR, and also demonstrated a significant increase in paracellular connective tissue in the outer layer of smooth muscle. Such major morphological alterations in the outer layer of smooth muscle in the portal vein from SHR could have profound effects on functional studies.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vena Porta
/
Ratas Endogámicas SHR
/
Hipertensión
/
Músculo Liso Vascular
Límite:
Animals
Idioma:
En
Revista:
Arch Histol Cytol
Asunto de la revista:
HISTOLOGIA
Año:
1992
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Japón