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Decreased plasma prolactin release in euthymic lithium-treated women with bipolar disorder.
El Khoury, Aram; Tham, Anne; Mathé, Aleksander A; Aberg-Wistedt, Anna; Stain-Malmgren, Rigmor.
Afiliación
  • El Khoury A; Department of Physiology and Pharmacology, Division of Pharmacology, Karolinska Institutet, Psychiatric Clinic, St. Göran's Hospital, Stockholm, Sweden. aram.el.khoury@cns.ki.se
Neuropsychobiology ; 48(1): 14-8, 2003.
Article en En | MEDLINE | ID: mdl-12886035
In order to evaluate the effect of treatment with citalopram (CIT) and lithium (Li) on hormone levels in women with bipolar disorder, morning plasma prolactin (PRL) and cortisol (CORT) were measured in 14 nonmedicated depressed patients, 13 depressed patients responding to CIT treatment, 17 euthymic patients on long-term Li treatment, and 11 healthy controls. Plasma PRL values in the Li group were significantly lower than those of the three other groups, suggesting a net inhibitory impact of augmentative effects of Li on dopaminergic activity and serotonergic neurotransmission in the central nervous system. Plasma CORT values in nonmedicated depressed patients were significantly higher than those of healthy controls, indicating hyperactivity of the hypothalamic-pituitary-adrenal system in depression, which appears to be a state-dependent phenomenon, and is normalized upon successful treatment with Li and CIT.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolactina / Trastorno Bipolar / Carbonato de Litio / Antidepresivos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Neuropsychobiology Año: 2003 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Suiza
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prolactina / Trastorno Bipolar / Carbonato de Litio / Antidepresivos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Neuropsychobiology Año: 2003 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Suiza