Antioxidant properties of galantamine hydrobromide.
Z Naturforsch C J Biosci
; 58(5-6): 361-5, 2003.
Article
en En
| MEDLINE
| ID: mdl-12872930
The antioxidant properties of galantamine hydrobromide ((4alpha,6beta)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide) were studied in vitro, using luminol-dependent chemiluminescence and spectrophotometry. It was found that this compound was a scavenger of reactive oxygen species (ROS). By comparing the antioxidant effects of galantamine ((4alpha,6beta)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol), galantamine hydrobromide, narwedine (4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one), and narwedine hydrobromide it was found that the antioxidant activity depended on the enolic OH group in the molecule. The presence of a quaternary nitrogen in the compound increased the strength of the scavenging effect. It is proposed that the antioxidant properties observed in vitro may contribute to the therapeutical effect of galantamine hydrobromide on patients with brain degeneration.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Galantamina
/
Antioxidantes
Idioma:
En
Revista:
Z Naturforsch C J Biosci
Año:
2003
Tipo del documento:
Article
País de afiliación:
Bulgaria
Pais de publicación:
Alemania