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Antiphospholipid/antiprotein antibodies, hemostasis-related autoantibodies, and plasma homocysteine as risk factors for a first early pregnancy loss: a matched case-control study.
Gris, Jean-Christophe; Perneger, Thomas V; Quéré, Isabelle; Mercier, Eric; Fabbro-Peray, Pascale; Lavigne-Lissalde, Géraldine; Hoffet, Médéric; Déchaud, Hervé; Boyer, Jean-Christophe; Ripart-Neveu, Sylvie; Tailland, Marie-Laure; Daurès, Jean-Pierre; Marès, Pierre; Dauzat, Michel.
Afiliación
  • Gris JC; Haematology Laboratory, University Hospital, F-30029 Nimes cedex 9, France. jcgris@chu-nimes.fr
Blood ; 102(10): 3504-13, 2003 Nov 15.
Article en En | MEDLINE | ID: mdl-12869511
Maternal hypercoagulability is a possible cause of miscarriage during the eighth and ninth weeks of pregnancy, when the placenta replaces the yolk sac. We thus examined associations between putative markers of an acquired hypercoagulable state and the risk of first miscarriage. We conducted a case-control study comparing 743 women who miscarried in weeks 8 and 9 with 743 women who underwent a first provoked abortion, matched for age, number of pregnancies, and time elapsed since abortion. Levels of plasma homocysteine and of various antiphospholipid/antiprotein and hemostasis-related autoantibodies were categorized in 4 strata (percentiles 1-80, 81-95, 96-99, 100 among control patients) and analyzed in conditional logistic regression models. Pregnancy loss was independently associated with positive lupus anticoagulant (matched odds ratio [OR], 2.6; 95% confidence interval [CI], 1.1-6.0), high levels of immunoglobulin M (IgM) antibodies against cardiolipin (OR for percentile 100 versus 0-80, 3.5; CI, 1.2-10.1) and against phosphatidylethanolamine (OR, 4.7; CI, 1.9-12.1), high levels of IgG antibodies against annexin V (OR, 3.2; CI, 1.1-9.1) and against tissue-type plasminogen activator (OR, 19.5; CI, 7.9-48.0), and high homocystinemia (OR, 4.1; CI, 1.3-12.5). A first early pregnancy loss is associated with increased levels of several autoantibodies and of homocysteine.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Aborto Espontáneo / Hemostasis / Homocisteína Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Blood Año: 2003 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Aborto Espontáneo / Hemostasis / Homocisteína Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Blood Año: 2003 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos