[Bronchial anthracosis and pulmonary mica overload]. / Anthracose bronchique et surcharge pulmonaire en micas.
Rev Mal Respir
; 20(2 Pt 1): 267-71, 2003 Apr.
Article
en Fr
| MEDLINE
| ID: mdl-12844024
INTRODUCTION: The discovery of anthracotic plaques generally suggests either a history of tuberculosis or occupational exposure to dust. Other etiologies should, however, be considered. CASE REPORTS: A 60-year-old Iranian woman presented with a history of dyspnoea and with chest radiography demonstrating calcified hilar lymph nodes and interstitial lung disease. Pulmonary function tests revealed airway obstruction. A diffuse bronchial inflammatory appearance accompanied by anthracotic plaques was found at bronchoscopy, which prompted transmission electron microscopy analysis of non-fibrous mineral particles in the bronchoalveolar lavage fluid (BALF). This demonstrated the presence of an alveolar particle count greater than 10(7) particles/ml (p/ml), significantly more than that found in 42 BALF samples taken from controls without a history of occupational dust exposure (4,4.10(5) p/ml). Furthermore, the analysis also revealed an abnormally elevated proportion of mica particles (64%). Two other individuals, a 68 year-old Moroccan woman and a 70-year-old Algerian woman, who had anthracotic plaques, but no radiological evidence of interstitial lung disease, also underwent mineral analysis of BALF. Neither were found to have a raised alveolar particle count, but the mineral profile showed an abnormally elevated proportion of micas (62%) for one patient, and silica crystalline (40%) as well as micas (32%) for the other patient. CONCLUSIONS: Even if mica is present in 30 to 90% of the BALF, the results observed in these three patients raises the possibility of non-occupational environmental exposure and that anthracotic plaques might be associated with domestic pollution.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bronquitis
/
Líquido del Lavado Bronquioalveolar
/
Silicatos de Aluminio
/
Antracosilicosis
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Middle aged
País/Región como asunto:
Africa
/
Asia
/
Europa
Idioma:
Fr
Revista:
Rev Mal Respir
Año:
2003
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia