Progress toward the development of a bacterial vaccine vector that induces high-titer long-lived broadly neutralizing antibodies against HIV-1.
FEMS Immunol Med Microbiol
; 37(2-3): 129-34, 2003 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-12832116
Conformationally constrained HIV-1 Env and gp120 immunogens induce broadly cross-reactive neutralizing antibodies. Thus, it is now feasible to rationally design an HIV-1 vaccine that affords protection through humoral mechanisms. This paper reviews our progress toward the development of an oral bacterial vaccine vector that is capable of delivering an HIV-1 DNA vaccine to host lymphoid tissues and inducing broadly neutralizing antibodies to HIV-1 in the mucosal and systemic immune compartments.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas Bacterianas
/
Anticuerpos Anti-VIH
/
Productos del Gen env
/
Proteína gp120 de Envoltorio del VIH
/
Vacunas contra el SIDA
/
Vectores Genéticos
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
FEMS Immunol Med Microbiol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido