Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects.

Wenyi, Z; Suzuki, S; Hirai, M; Hinokio, Y; Tanizawa, Y; Matsutani, A; Satoh, J; Oka, Y

Wenyi, Z; Suzuki, S; Hirai, M; Hinokio, Y; Tanizawa, Y; Matsutani, A; Satoh, J; Oka, Y.

Afiliación

Wenyi Z; Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

Diabetologia ; 46(7): 972-6, 2003 Jul.

Article en En | MEDLINE | ID: mdl-12830381

RESUMEN

AIM/HYPOTHESIS: Urotensin II is a potent vasoactive hormone and the urotensin II gene (UTS2) is localized to 1p36-p32, one of the regions reported to show possible linkage with Type 2 diabetes in Japanese subjects. The aim of this study is to investigate a possible contribution of SNPs in the UTS2 gene to the development of Type 2 diabetes. METHODS: We surveyed SNPs in the UTS2 gene in 152 Japanese subjects with Type 2 diabetes mellitus and two control Japanese cohorts: one consisting of 122 elderly subjects who met stringent criteria for being non-diabetic, including being older than 60 years of age with no evidence of diabetes (HbA(1c)<5.6%), and another 268 subjects with normal glucose tolerance. RESULTS: We identified two SNPs with amino acid substitutions, designated T21M and S89N. The allele frequency of 89N was higher in Type 2 diabetic patients than in both elderly normal subjects (p=0.0018) and subjects with normal glucose tolerance (p=0.0011), whereas the allele frequency of T21M was essentially identical in these three groups. Furthermore, in the subjects with normal glucose tolerance, 89N was associated with higher insulin concentrations on oral glucose tolerance test, suggesting reduced insulin sensitivity in subjects with 89N. CONCLUSION/INTERPRETATION: These results strongly suggest that the S89N polymorphism in the UTS2 gene is associated with the development of Type 2 diabetes, via insulin sensitivity, in Japanese subjects.

Asunto(s)

Diabetes Mellitus Tipo 2/genética; Predisposición Genética a la Enfermedad/genética; Intolerancia a la Glucosa/genética; Polimorfismo de Nucleótido Simple; Urotensinas/genética; Anciano; Empalme Alternativo; Pueblo Asiatico/genética; Glucemia/metabolismo; Diabetes Mellitus Tipo 2/dietoterapia; Diabetes Mellitus Tipo 2/tratamiento farmacológico; Femenino; Amplificación de Genes; Prueba de Tolerancia a la Glucosa; Humanos; Insulina/sangre; Resistencia a la Insulina/genética; Japón; Masculino; Persona de Mediana Edad; Reacción en Cadena de la Polimerasa; Polimorfismo de Longitud del Fragmento de Restricción

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Urotensinas / Intolerancia a la Glucosa / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Diabetes Mellitus Tipo 2 Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Diabetologia Año: 2003 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania

Buscar en Google

Añadir a Mi BVS

Imprimir

XML

PubMed Links