A regioselective approach to 5-substituted-3-amino-1,2,4-triazines.

Limanto, John; Desmond, Richard A; Gauthier, Donald R; Devine, Paul N; Reamer, Robert A; Volante, R P

Limanto, John; Desmond, Richard A; Gauthier, Donald R; Devine, Paul N; Reamer, Robert A; Volante, R P.

Afiliación

Limanto J; Department of Process Research, Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, NJ 07065, USA. john_limanto@merck.com

Org Lett ; 5(13): 2271-4, 2003 Jun 26.

Article en En | MEDLINE | ID: mdl-12816426

RESUMEN

Nucleophilic displacement of readily available alpha,alpha-dibromoketones with excess morpholine gave the corresponding ketoaminals, which upon condensation with aminoguanidine in MeOH in the presence of AcOH afforded 5-substituted-3-amino-1,2,4-triazines in >95% regioselectivity and 45-76% isolated yield. [reaction: see text]

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Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2003 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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