Bioactive crude plant seed extracts from the NCAUR oilseed repository.

Cantrell, C L; Berhow, M A; Phillips, B S; Duval, S M; Weisleder, D; Vaughn, S F

Cantrell, C L; Berhow, M A; Phillips, B S; Duval, S M; Weisleder, D; Vaughn, S F.

Afiliación

Cantrell CL; U.S. Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, Illinois, USA. c.cantrell@hauser.com

Phytomedicine ; 10(4): 325-33, 2003 May.

Article en En | MEDLINE | ID: mdl-12809363

RESUMEN

Over four-hundred crude extracts from 202 plant species distributed among 131 plant families were evaluated for their bioactivity against brine shrimp (Artemia salina). Activity was determined for both the organic (CH2Cl2:MeOH) and aqueous extracts against A. salina in a 96 well-plate assay. Of the greater than four-hundred extracts tested, 21 organic and 6 aqueous extracts demonstrated potent cytotoxic activity (LC50 = < 100 microg/ml). Three of these organic extracts (Crateva religiosa, Diospyros dichrophylla, and Olax subscorpioidea) were chosen for chemical investigations due to their high activity and a lack of prior investigations. Chemical analysis of these extracts resulted in the isolation of oleanolic acid (1) and 4-epi-hederagenin (2) from C. religiosa, isodiospyrin (3) from D. dichrophylla, and santalbic acid (4) from O. subscorpioidea.

Asunto(s)

Fitoterapia; Extractos Vegetales/farmacología; Plantas Medicinales; Animales; Artemia/efectos de los fármacos; Capparaceae; Diospyros; Dosificación Letal Mediana; Olacaceae; Semillas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Extractos Vegetales / Fitoterapia Límite: Animals Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2003 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania

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