NSD1 is essential for early post-implantation development and has a catalytically active SET domain.
EMBO J
; 22(12): 3153-63, 2003 Jun 16.
Article
en En
| MEDLINE
| ID: mdl-12805229
The nuclear receptor-binding SET domain-containing protein (NSD1) belongs to an emerging family of proteins, which have all been implicated in human malignancy. To gain insight into the biological functions of NSD1, we have generated NSD1-deficient mice by gene disruption. Homozygous mutant NSD1 embryos, which initiate mesoderm formation, display a high incidence of apoptosis and fail to complete gastrulation, indicating that NSD1 is a developmental regulatory protein that exerts function(s) essential for early post-implantation development. We have also examined the enzymatic potential of NSD1 and found that its SET domain possesses intrinsic histone methyltransferase activity with specificity for Lys36 of histone H3 (H3-K36) and Lys20 of histone H4 (H4-K20).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
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Proteínas Portadoras
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N-Metiltransferasa de Histona-Lisina
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Péptidos y Proteínas de Señalización Intracelular
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Desarrollo Embrionario
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Embrión de Mamíferos
Límite:
Animals
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
EMBO J
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido