Antimicrobial diterpenes from the seeds of Cephalotaxus harringtonia var. drupacea.
Planta Med
; 69(5): 468-70, 2003 May.
Article
en En
| MEDLINE
| ID: mdl-12802733
Six diterpenes, including two new natural products, were isolated from the seeds of Cephalotaxus harringtonia. The new metabolites were characterised as 8 beta-hydroxy-9(11),13-abietadien-12-one and 5,6-didehydroferruginol, while the known compounds were identified as ferruginol, sugiol, 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one, and abieta-8,11,13-trien-7 beta-ol. These compounds were studied in vitro for their antimicrobial activity against clinically isolated bacteria and Candida strains. Ferruginol and 6,12-dihydroxyabieta-5,8,11,13-tetraen-7-one showed antimicrobial activity against Gram-positive bacteria. None of the six diterpenes was active against the Gram-negative organisms and yeasts tested.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Cephalotaxus
/
Diterpenos
/
Fitoterapia
/
Antiinfecciosos
/
Antifúngicos
Límite:
Humans
Idioma:
En
Revista:
Planta Med
Año:
2003
Tipo del documento:
Article
Pais de publicación:
Alemania