Intermittent extremely low frequency electromagnetic fields cause DNA damage in a dose-dependent way.
Int Arch Occup Environ Health
; 76(6): 431-6, 2003 Jul.
Article
en En
| MEDLINE
| ID: mdl-12802592
OBJECTIVES: Epidemiological studies have reported an association between exposure to extremely low frequency electromagnetic fields (ELF-EMFs) and increased risk of cancerous diseases, albeit without dose-effect relationships. The validity of such findings can be corroborated only by demonstration of dose-dependent DNA-damaging effects of ELF-EMFs in cells of human origin in vitro. METHODS: Cultured human diploid fibroblasts were exposed to intermittent ELF electromagnetic fields. DNA damage was determined by alkaline and neutral comet assay. RESULTS: ELF-EMF exposure (50 Hz, sinusoidal, 1-24 h, 20-1,000 mu T, 5 min on/10 min off) induced dose-dependent and time-dependent DNA single-strand and double-strand breaks. Effects occurred at a magnetic flux density as low as 35 mu T, being well below proposed International Commission of Non-Ionising Radiation Protection (ICNIRP) guidelines. After termination of exposure the induced comet tail factors returned to normal within 9 h. CONCLUSION: The induced DNA damage is not based on thermal effects and arouses concern about environmental threshold limit values for ELF exposure.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Campos Electromagnéticos
Límite:
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int Arch Occup Environ Health
Año:
2003
Tipo del documento:
Article
País de afiliación:
Austria
Pais de publicación:
Alemania