Tissue hypoxia and intestinal dysbiosis in children with tuberculosis.
Bull Exp Biol Med
; 135(2): 178-80, 2003 Feb.
Article
en En
| MEDLINE
| ID: mdl-12802429
We studied the role of autochthonous microflora from body cavities in the development of tissue hypoxia and instability of cell membranes. In children with tuberculosis dysbiosis manifested in nonspecific quantitative changes in the intestinal microflora and the presence of coxsackievirus antigens in the urine. DNA-containing viruses with pronounced immunosuppressive activity (e.g., herpesvirus, measles virus, and rubella virus) were found in most children. Microbiological and virological changes were accompanied by the appearance of laboratory signs for tissue hypoxia, which included inhibition of Krebs cycle dehydrogenases and alpha-glycerophosphate pathway in blood lymphocytes. Regression analysis revealed a relationship between the content of extraintestinal coxsackieviruses and inactivation of alpha-glycerophosphate dehydrogenase, succinate dehydrogenase and ratio of facultatively anaerobic bacteria in microbiocenosis, and expression of acid phosphatase and total population of malonate-positive enterobacteria, staphylococci, yeasts, and enterococci.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Intestinos
/
Hipoxia
Límite:
Child
/
Child, preschool
/
Humans
/
Infant
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2003
Tipo del documento:
Article
Pais de publicación:
Estados Unidos