Cellular and molecular action of the putative GABA-mimetic, gabapentin.
Cell Mol Life Sci
; 60(4): 742-50, 2003 Apr.
Article
en En
| MEDLINE
| ID: mdl-12785720
Gabapentin was originally designed as an anti-convulsant gamma-aminobutyric acid (GABA) mimetic capable of crossing the blood-brain barrier. In the present review we show that although gabapentin is not a GABA mimetic, it has great utility as an add-on therapy for epilepsy and as a first-line treatment for neuropathic pain. We summarise the studies that have been performed which demonstrate that gabapentin appears to interact with a novel binding site expressed at high density within the central nervous system (CNS), namely the alpha2delta voltage-dependent calcium channel subunit. The review continues by examining the effects of gabapentin on calcium channel function and neurotransmitter release before, in the latter part of the review, summarising the more recently discovered actions of gabapentin in relation to intracellular signalling.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Convulsiones
/
Ácidos Ciclohexanocarboxílicos
/
Aminas
/
Analgésicos
/
Acetatos
/
Anticonvulsivantes
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Mol Life Sci
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2003
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Suiza