Streptozotocin-induced diabetes modulates presynaptic and postsynaptic function in the rat ileum.
Eur J Pharmacol
; 469(1-3): 153-8, 2003 May 23.
Article
en En
| MEDLINE
| ID: mdl-12782197
Altered gastrointestinal motility frequently occurs in diabetic patients and also in animal models of diabetes but the underlying causes are not clear. In the present study, contractile responses to agonists and electrical field stimulation (EFS) and the inhibitory actions of an adenosine A(1) receptor agonist were investigated on ilea from 8-week streptozotocin (STZ)-induced diabetic rats. Contractile responses to carbachol, prostaglandin F(2 alpha) (PGF(2 alpha)), the calcium ionophore A23187 and to EFS were increased in diabetic tissues compared to controls. In contrast, the inhibitory effects of a potent and selective adenosine A(1) receptor agonist N(6)-cyclopentyladenosine (CPA) on electrical field stimulation-evoked contractions were decreased in diabetic tissues compared to controls but its ability to relax carbachol-contracted tissues was unaltered. These results suggest that diabetes may cause alterations at both pre- and postsynaptic sites and this may lead in turn to the gastrointestinal complications seen in diabetic patients.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Terminales Presinápticos
/
Diabetes Mellitus Experimental
/
Íleon
/
Contracción Muscular
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
2003
Tipo del documento:
Article
País de afiliación:
Tailandia
Pais de publicación:
Países Bajos