Amplification of the BCR/ABL fusion gene clustered on a masked Philadelphia chromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia.
Cancer Genet Cytogenet
; 143(2): 140-4, 2003 Jun.
Article
en En
| MEDLINE
| ID: mdl-12781448
Although the chronic phase of chronic myelocytic leukemia (CML) is characterized by the Philadelphia (Ph) chromosome creating a hybrid BCR/ABL gene, additional genetic changes involved in blast crisis are poorly understood. We report a 4-8-fold amplification by tandem duplication of the BCR/ABL fusion gene clustered on a masked Ph chromosome in a 61-year-old male patient with CML in myeloblastic crisis. Our finding suggests that the BCR/ABL amplification may play a role as a novel mechanism in the progression to an aggressive blast transformation in some cases of Ph-positive CML.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromosoma Filadelfia
/
Leucemia Mielógena Crónica BCR-ABL Positiva
/
Amplificación de Genes
/
Familia de Multigenes
/
Proteínas de Fusión bcr-abl
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
2003
Tipo del documento:
Article
País de afiliación:
Argentina
Pais de publicación:
Estados Unidos