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Role of elastase in a mouse model of chronic respiratory Pseudomonas aeruginosa infection that mimics diffuse panbronchiolitis.
Yanagihara, Katsunori; Tomono, Kazunori; Kaneko, Yukihiro; Miyazaki, Yoshitsugu; Tsukamoto, Kazuhiro; Hirakata, Yoichi; Mukae, Hiroshi; Kadota, Jun-Ichi; Murata, Ikuo; Kohno, Shigeru.
Afiliación
  • Yanagihara K; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan 2Department of Pharmacotherapeutics, Nagasaki University Graduate School of Phamaceutical Sciences, Nagasaki, Japan 3Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology a
  • Tomono K; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan 2Department of Pharmacotherapeutics, Nagasaki University Graduate School of Phamaceutical Sciences, Nagasaki, Japan 3Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology a
  • Kaneko Y; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan 2Department of Pharmacotherapeutics, Nagasaki University Graduate School of Phamaceutical Sciences, Nagasaki, Japan 3Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology a
  • Miyazaki Y; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan 2Department of Pharmacotherapeutics, Nagasaki University Graduate School of Phamaceutical Sciences, Nagasaki, Japan 3Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology a
  • Tsukamoto K; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan 2Department of Pharmacotherapeutics, Nagasaki University Graduate School of Phamaceutical Sciences, Nagasaki, Japan 3Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology a
  • Hirakata Y; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan 2Department of Pharmacotherapeutics, Nagasaki University Graduate School of Phamaceutical Sciences, Nagasaki, Japan 3Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology a
  • Mukae H; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan 2Department of Pharmacotherapeutics, Nagasaki University Graduate School of Phamaceutical Sciences, Nagasaki, Japan 3Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology a
  • Kadota JI; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan 2Department of Pharmacotherapeutics, Nagasaki University Graduate School of Phamaceutical Sciences, Nagasaki, Japan 3Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology a
  • Murata I; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan 2Department of Pharmacotherapeutics, Nagasaki University Graduate School of Phamaceutical Sciences, Nagasaki, Japan 3Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology a
  • Kohno S; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan 2Department of Pharmacotherapeutics, Nagasaki University Graduate School of Phamaceutical Sciences, Nagasaki, Japan 3Division of Molecular and Clinical Microbiology, Department of Molecular Microbiology a
J Med Microbiol ; 52(Pt 6): 531-535, 2003 Jun.
Article en En | MEDLINE | ID: mdl-12748275
Pseudomonas aeruginosa frequently colonizes the respiratory tract of patients suffering from cystic fibrosis (CF) and diffuse panbronchiolitis (DPB). However, the relationship between lung inflammation and extracellular products of P. aeruginosa is not well-defined. To assess the role of elastase released by P. aeruginosa in DPB, a murine model of DPB was employed in this study. Mice were inoculated with either P. aeruginosa PAO1 or PAO-E64; the latter produces elastase with greatly reduced enzymic activity. Throughout the 90-day experiments, counts of viable bacteria from the PAO1- and PAO-E64-infected mice were found to be equivalent. However, the number of lymphocytes isolated from the lungs of PAO-E64-infected mice was significantly lower than the number isolated from the lungs of PAO1-infected animals. Histopathological examination of the lungs of mice infected by PAO1 on day 90 revealed an intense accumulation of chronic respiratory cells surrounding the bronchi, in sharp contrast to the more localized inflammatory response found in those mice infected by PAO-E64. These data suggest that P. aeruginosa elastase (PE) is a potent inflammatory factor in a mouse model of DPB and that the control of PE release by P. aeruginosa may be beneficial for patients with DPB.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas / Bronquiolitis / Elastasa Pancreática / Fibrosis Quística Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Med Microbiol Año: 2003 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Infecciones por Pseudomonas / Bronquiolitis / Elastasa Pancreática / Fibrosis Quística Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Med Microbiol Año: 2003 Tipo del documento: Article Pais de publicación: Reino Unido