Lack of association between the HLA-A10 (A25), B18 and C2o haplotype and anaphylactoid purpura (AP).

Krüger, J; Opferkuch, W; Evers, K G; Bosecker, L; Haase, W

Krüger, J; Opferkuch, W; Evers, K G; Bosecker, L; Haase, W.

Afiliación

Krüger J; Department of Blood Transfusion of the University of Cologne, Germany.

Tissue Antigens ; 15(1): 68-74, 1980 Jan.

Article en En | MEDLINE | ID: mdl-12735335

RESUMEN

In 41 patients with AP and 134 healthy relatives HLA haplotypes and total hemolytic complement and C2 concentrations were determined. Though complement levels were found in the lower normal range in none of the individuals studied, a genetically determined C2 deficient state could be established. No association between low C2 levels and the HLA haplotype A10(A25), B18 or an isolated A25 or B18 was observed. A comparison of phenotype frequencies of AP patients with controls showed no significant difference. Contingency table analysis of patients and control haplotypes showed a definite close association with HLA-A1, Bw22, A2, Bw16, and A29, B12.

Asunto(s)

Complemento C2/genética; Antígenos HLA-A/genética; Vasculitis por IgA/genética; Vasculitis por IgA/inmunología; Adolescente; Niño; Preescolar; Femenino; Predisposición Genética a la Enfermedad/genética; Haplotipos; Humanos; Lactante; Masculino; Fenotipo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasculitis por IgA / Complemento C2 / Antígenos HLA-A Tipo de estudio: Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Tissue Antigens Año: 1980 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido

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