RNA polymerase holoenzyme: structure, function and biological implications.
Curr Opin Microbiol
; 6(2): 93-100, 2003 Apr.
Article
en En
| MEDLINE
| ID: mdl-12732296
The past three years have marked the breakthrough in our understanding of the structural and functional organization of RNA polymerase. The latest major advance was the high-resolution structures of bacterial RNA polymerase holoenzyme and the holoenzyme in complex with promoter DNA. Together with an array of genetic, biochemical and biophysical data accumulated to date, the structures provide a comprehensive view of dynamic interactions between the major components of transcription machinery during the early stages of the transcription cycle. They include the binding of sigma factor to the core enzyme, and the recognition of promoter sequences and DNA melting by holoenzyme, transcription initiation and promoter clearance.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacterias
/
ARN Polimerasas Dirigidas por ADN
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Curr Opin Microbiol
Asunto de la revista:
MICROBIOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido