Spontaneous squamous cysts and squamous epithelial plaques in the heart of cynomolgus monkeys (Macaca fascicularis).
Exp Toxicol Pathol
; 54(4): 301-3, 2003 Mar.
Article
en En
| MEDLINE
| ID: mdl-12710713
Squamous cysts and squamous epithelial plaques were observed in a total of seventeen cynomolgus monkeys. Eleven monkeys had squamous cysts, three of them also revealed squamous plaques and six revealed squamous plaques exclusively. At necropsy, cysts were recognized as yellow-white nodules with a smooth surface, that were located superficially along the interventricular septum, on the surface of the left ventricle or the apex of the heart. Microscopically, cysts were lined by a flattened epithelium and filled with keratin. Occasionally the epithelium was multi-layered or replaced by a rim of foreign body-type multinucleated giant cells. All animals with squamous cysts came from Mauritius, while those with squamous plaques came from Mauritius, China and Vietnam. As discussed in man, squamous cysts and plaques in cynomolgus monkeys are considered to represent displaced foregut epithelium, that was sequestered in the dorsal mesocardium prior to closure of the pleuropericardial fold during early embryologic development.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quistes
/
Epitelio
/
Enfermedades de los Monos
/
Cardiomiopatías
Límite:
Animals
Idioma:
En
Revista:
Exp Toxicol Pathol
Asunto de la revista:
PATOLOGIA
/
TOXICOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania