Humoral immune response and assessment of vaccine virus shedding in calves receiving modified live virus vaccines containing bovine herpesvirus-1 and bovine viral diarrhoea virus 1a.
J Vet Med B Infect Dis Vet Public Health
; 50(1): 31-7, 2003 Feb.
Article
en En
| MEDLINE
| ID: mdl-12710498
Susceptible calves were administered modified live virus (MLV) vaccines containing bovine herpesvirus-1 (BHV1) and bovine viral diarrhoea type 1 (BVDV1a) strains intramuscularly, with one vaccine containing both MLV and inactivated BHV-1 and inactivated BVDV1a. There was no evidence of transmission of vaccine (BHV-1 and BVDV1a) strains to susceptible non-vaccinated controls commingled with vaccinates. No vaccinates had detectable BHV-1 in peripheral blood leucocytes (PBL) after vaccination. Each of three vaccines containing an MLV BVDV1a strain caused a transient BVDV vaccine induced viremia in PBL after vaccination, which was cleared as the calves developed serum BVDV1 antibodies. The vaccine containing both MLV and inactivated BHV-1 induced serum BHV-1 antibodies more rapid than MLV BHV-1 vaccine. Two doses of MLV BHV-1 (days 0 and 28) in some cases induced serum BHV-1 antibodies to higher levels and greater duration than one dose.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diarrea Mucosa Bovina Viral
/
Vacunas Virales
/
Virus de la Diarrea Viral Bovina
/
Herpesvirus Bovino 1
/
Anticuerpos Antivirales
Límite:
Animals
Idioma:
En
Revista:
J Vet Med B Infect Dis Vet Public Health
Asunto de la revista:
MEDICINA VETERINARIA
/
SAUDE PUBLICA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Alemania