Genetic interactions provide evidence for the role of integrins in specifying normal olfactory behavior in Drosophila melanogaster.
J Neurogenet
; 16(3): 165-74, 2002.
Article
en En
| MEDLINE
| ID: mdl-12696671
In a previous paper, we showed that weak hypomorphic alleles at the myospheroid (mys) locus, which encodes the beta-subunit of integrin, possess defects in olfactory behavior in both adult and larva. In this paper, we show that another olfactory gene, olfE, exhibits haploinsufficient interactions with recessive alleles at the mys locus. olfE has recently been shown to be an allele of swisscheese and is now designated as sws(olfE). Our findings suggest an interaction between the sws protein and beta-integrin in the development and/or functioning of the olfactory system. Similar interactions were also observed between sws and inflated, a gene encoding the alpha2-subunit of integrin, as well as mys and multiple edematous wing (mew), a gene coding for alpha1 subunit of integrin. This study provides evidence for the roles of different integrin subunits and the sws product in regulating normal olfactory behavior in Drosophila.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Olfato
/
Integrinas
/
Genes de Insecto
/
Proteínas de Drosophila
/
Drosophila melanogaster
Límite:
Animals
Idioma:
En
Revista:
J Neurogenet
Año:
2002
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Reino Unido