Multidipole analysis of simulated epileptic spikes with real background activity.
J Clin Neurophysiol
; 20(1): 1-16, 2003 Feb.
Article
en En
| MEDLINE
| ID: mdl-12684553
This simulated magnetoencephalographic study was designed to determine the variability in source parameters with real subject background activity when applying multidipole spatial-temporal dipole analyses, for which the correct model was compared with undermodeled and overmodeled cases. The simulated sources were created from patches of the cortical surface of each subject's MRI. One- and two-source frontal lobe spikes were generated in two cortical regions seen commonly in frontal lobe epilepsy patients tested at our site (orbital frontal and premotor cortex). In general, the modeling results were adequate for the correct model order and the correct model order plus one. In addition, if the localization error was less than 10 mm from the simulated source, the peak latency of the spike and orientation were very reliable, but the peak amplitude was not. The additional source in the overmodeled condition, on the other hand, was not localized reliably across the different epochs within subjects. The results suggest that consistency of the spike localization and inconsistency of other sources will allow one to determine reliably the appropriate model order in real data, and therefore determine single and multifocal spike generators.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Simulación por Computador
/
Mapeo Encefálico
/
Magnetoencefalografía
/
Epilepsia del Lóbulo Frontal
/
Modelos Neurológicos
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Clin Neurophysiol
Asunto de la revista:
FISIOLOGIA
/
NEUROLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos