Expressions of latent membrane protein 1, p53 and bcl-2 proteins and their significance in Hodgkin's lymphoma.
Di Yi Jun Yi Da Xue Xue Bao
; 23(3): 225-7, 2003 Mar.
Article
en En
| MEDLINE
| ID: mdl-12651235
OBJECTIVE: To study the expressions of latent membrane protein 1 (LMP1), p53 and bcl-2 proteins and investigate their significance in the pathogenesis of Hodgkin's lymphoma. METHODS: Immunohistochemical staining was used to examine the expressions of LMP1, bcl-2, and p53 proteins in 31 paraffin-embedded tissue samples from Hodgkin's lymphoma. RESULT: The positivity rates of LMP1, p53 and bcl-2 proteins were 58.1% (18/31), 61.3% (19/31) and 35.5% (11/31), respectively, showing a statistically significant difference between the expressions of the former 2 proteins. CONCLUSION: p53 may be involved as an important agent in the pathogenesis of Hodgkin's lymphoma induced by LMP1, whereas bcl-2 appears unrelated to the development of this disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Hodgkin
/
Proteínas de la Matriz Viral
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Proteína p53 Supresora de Tumor
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Proteínas Proto-Oncogénicas c-bcl-2
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Di Yi Jun Yi Da Xue Xue Bao
Asunto de la revista:
MEDICINA
Año:
2003
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China