Antimetabolites produced by microorganisms. XV Synthesis of 2-methyl-L-arginine, 2-methyl-L-ornithine and their enantiomers.
J Antibiot (Tokyo)
; 29(3): 221-6, 1976 Mar.
Article
en En
| MEDLINE
| ID: mdl-1262253
5-(3-Azidopropyl)-5-methyl-2, 4-imidazolidinedione was prepared either from 5-(3-chloropropyl)-5-methyl-2,4-imidazolidinedione or 5-methyl-5-(3-[(4-methylphenyl)sulfonyloxy]-propyl)-5-methyl-2, 4-imidazolidinedione and hydrogenolyzed to the corresponding amine which, after carbamimidoylation, afforded 2-methyl-DL-arginine upon acid hydrolysis. Racemic 2-methylarginine was converted enzymically to a mixture of 2-methyl-D-arginine and 2-methyl-L-ornithine. 2-Methyl-L-arginine was reconstructed from 2-methyl-L-ornithine via its Cu(II) chelate with O-methyl-isourea and 2-methyl-D-ornithine was obtained by alkaline hydrolysis of 2-methyl-D-arginine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ornitina
/
Arginina
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
1976
Tipo del documento:
Article
Pais de publicación:
Reino Unido