Determination of nabumetone in pharmaceutical formulation by flow injection analysis (FIA) with UV-detection.
Pharmazie
; 58(1): 22-4, 2003 Jan.
Article
en En
| MEDLINE
| ID: mdl-12622247
A precise and accurate FIA method for the quantification of nabumetone (NAB) in pharmaceuticals is described. The best suitable carrier solvent system consisted of ethanol: water (30:70 v/v). Sample solution (4.7 x 10(-6) M NAB) was prepared in this solvent and injected to the instrumental system at a flow rate of 1.2 ml x min(-1). The signals were detected by a UV detector at 228.8 nm. The calibration curves of NAB was linear in the concentration range of 1.4 x 10(-6) M-2.8 x 10(-5) M. The intra- and inter-assay precision were less than 2.6%. The method exhibited a good linearity with the correlation coefficients. The LOD and LOQ values were found to be 4.4 x 10(-7) and 1.3 x 10(-6) M, respectively. The effects of the tablet excipients were insignificant at the 95% probability level. The calculated tablet content was 99% which is agreement with the ranges stated by pharmacopoeias.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Butanonas
/
Antiinflamatorios no Esteroideos
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Pharmazie
Asunto de la revista:
FARMACIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Alemania