Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas.
Lung Cancer
; 39(3): 273-7, 2003 Mar.
Article
en En
| MEDLINE
| ID: mdl-12609565
In this study we have examined 79 primary non-small cell lung tumours for the presence of mutations of the VHL gene as well as for allelic imbalance at the gene surrounding loci. While allelic imbalance was found in 83% of specimens, frequently affecting the whole 3p25-p26 region, no mutations were detected in the VHL coding region. The fractional regional loss (FRL) was significantly higher in squamous cell carcinomas (0.746) than adenocarcinomas (0.493) (Wilcoxon P=0.002). This is the first investigation of the VHL gene mutational status in primary lung tumours. Our results indicate that mutation is not a common means of VHL inactivation in NSCLC.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 3
/
Análisis Mutacional de ADN
/
Carcinoma de Células Escamosas
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Adenocarcinoma
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Genes Supresores de Tumor
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Carcinoma de Pulmón de Células no Pequeñas
/
Pérdida de Heterocigocidad
/
Proteínas Supresoras de Tumor
/
Ubiquitina-Proteína Ligasas
/
Ligasas
Límite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Lung Cancer
Asunto de la revista:
NEOPLASIAS
Año:
2003
Tipo del documento:
Article
Pais de publicación:
Irlanda