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Steady-state sVCAM-1 serum levels in adults with sickle cell disease.
Schnog, J B; Rojer, R A; Mac Gillavry, M R; Ten Cate, H; Brandjes, D P M; Duits, A J.
Afiliación
  • Schnog JB; Department of Internal Medicine, St. Elisabeth Hospital, Curaçao, Netherlands Antilles. jschnog@hotmail.com.
  • Rojer RA; Red Cross Bloodbank Curaçao, St. Elisabeth Hospital, Curaçao, Netherlands Antilles. jschnog@hotmail.com.
  • Mac Gillavry MR; Department of Internal Medicine (9B), Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. jschnog@hotmail.com.
  • Ten Cate H; Department of Internal Medicine, St. Elisabeth Hospital, Curaçao, Netherlands Antilles.
  • Brandjes DPM; Department of Internal Medicine (9B), Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands.
  • Duits AJ; Department of Internal Medicine (9B), Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands.
Ann Hematol ; 82(2): 109-113, 2003 Feb.
Article en En | MEDLINE | ID: mdl-12601490
Cytokines and adhesion molecules play an important role in the pathophysiology of vaso-occlusion in sickle cell disease (SCD), and their in vivo profiles are potential tools for assessing SCD severity. We compared steady-state soluble vascular cell adhesion molecule-1 (sVCAM-1) serum levels to clinical (painful crisis frequency, occurrence of acute chest syndrome, leg ulcers, and cerebrovascular disease) and related hematological parameters of SCD severity (such as HbF%, hemoglobin levels, and leukocyte counts) in 29 HbSS adults. Serum sVCAM-1 levels were not related to clinical severity, but an inverse correlation was demonstrated between sVCAM-1 and hemoglobin levels (r=-0.71, p<0.001) with a positive correlation to serum lactate dehydrogenase levels (r=0.59, p=0.008). Based upon these results, steady-state serum sVCAM-1 levels do not seem to reflect clinical disease severity. However, as VCAM-1 is involved in hematopoiesis, sVCAM-1 levels might reflect bone marrow activity in SCD. This underlies the pleiotropic nature of adhesion molecules in vivo and the need for further research in this area, especially since therapies targeting (cellular) adhesive interactions involving the endothelium are emerging for SCD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Molécula 1 de Adhesión Celular Vascular / Anemia de Células Falciformes Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2003 Tipo del documento: Article País de afiliación: Antillas Neerlandesas Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Severidad de la Enfermedad / Molécula 1 de Adhesión Celular Vascular / Anemia de Células Falciformes Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Hematol Asunto de la revista: HEMATOLOGIA Año: 2003 Tipo del documento: Article País de afiliación: Antillas Neerlandesas Pais de publicación: Alemania