Reproductive/developmental toxicity and immunotoxicity assessment in the nonhuman primate model.
Toxicology
; 185(3): 221-7, 2003 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-12581697
Nonhuman primates are being used increasingly as a non-rodent animal model during preclinical toxicology and safety assessment on the basis of proven similarity and comparability between nonhuman primates and humans. The validity of the nonhuman primate models applies to many aspects of toxicological testing and holds particularly true for the evaluation of reproductive toxicology and developmental toxicology. More recently, the advent of humanized antibodies and vaccines imposed further demand on nonhuman primate models since many immunotherapeutics do not interact with rodent receptors but frequently only cross-react with primate tissue. In this paper we discuss the suitability of primate models for reproductive, developmental and immunotoxicology testing, and present our initial data on the development of lymphatic organs and immune system in a nonhuman primate model.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Primates
/
Reproducción
/
Anomalías Inducidas por Medicamentos
/
Inmunotoxinas
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Toxicology
Año:
2003
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Irlanda